Caffeine, CYPA12 and Resistance Training

Influence of CYP1A2 on the Prolonged Effect of Caffeine Intake on Resistance Training

NCT06610123•Alberto Pérez-López

Summary

Introduction: Several studies have evaluated and confirmed the ergogenic effect of acute caffeine intake on sports performance, specifically on strength and power performance. However, it remains to be elucidated how CYP1A2 polymorphism influences the prolonged effects of caffeine on this type of exercise. Objectives: The present study aims to analyze the prolonged effects of caffeine intake on neuromuscular adaptations to resistance training according to CYP1A2 polymorphism in men and women.

Eligibility

Age

18 - 35 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Age between ≥ 18 and ≤ 35 years.
•Body mass index (BMI) lowe than 25 kg/m².
•Physically active subjects (≥ 150 min/week of moderate exercise).
•Healthy men and women without neurological, cardiometabolic, immunological, or physical conditions that prevent them from performing physical exercise.
•Participants capable of performing the tests.

Exclusion Criteria

•History of neuromuscular, cardiac, or diseases that could affect liver or muscle metabolism.
•Use of drugs or other stimulants that interfere with caffeine intake and intestinal absorption during the tests and study.
•Body mass index (BMI) ≥ 25 kg/m².
•Having undergone prolonged periods of forced physical inactivity during the 6 months prior to the study.
•Performing strenuous exercise within 48 hours prior to the tests.
•Failing to replicate the same food intake on the two experimental days.
•Consuming caffeine after 6 PM on the day prior to training or testing.

Locations (1)

Facultad de Medicina y Ciencias de la Salud. Universidad de Alcalá

Alcalá de Henares, Madrid, Spain

Key Dates

Start Date

April 1, 2024

Primary Completion Date

July 30, 2025

Completion Date

July 30, 2025

Last Updated

September 24, 2024

Enrollment

ESTIMATED participants

Conditions

CYP1A2 PolymorphismCaffeine and Resistance Training

Interventions

Caffeine and Resistance training

DIETARY_SUPPLEMENT

Placebo and Resistance training

DIETARY_SUPPLEMENT

Contacts

Alberto Pérez-López, PhD

CONTACT

918854537 alberto.perezl@uah.es