Effects of Exercise and Metformin on Methylglyoxal Levels in Prediabetic Individuals

Exclusion Criteria

• •having a serious medical condition that would prevent the person from participating in the exercise study (e.g. advanced malignancy or major neurological, psychiatric or endocrine disease, respiratory failure, etc.),
• •having used metformin for 6 months before the study, having cardiovascular disease,
• •heart failure, cancer, having a BMI \<19 kg/m2, receiving hormone replacement therapy,
• •having a life expectancy of less than 1 year, being HIV positive, substance use,
• •functional dependence, having an orthopedic disease that prevents physical activity,
• •having cognitive impairment and other diseases that would affect the study results (respiratory diseases, muscle diseases, non-alcoholic fatty liver disease, etc.),
• •using medications or supplements that would affect the study results.