SCLife®-LDD hUC-MSCs Injection Therapy for Patients With Lumbar Intervertebral Disc Degeneration

Exclusion Criteria

• •1. Previous history of tumor and spinal infection;
• •2. Patients with severe coagulation disorders, a history of drug abuse or taking oral anticoagulants;
• •3. Coma or incapacitation;
• •4. MRI contraindications (history of cardiovascular and cerebrovascular stent implantation, pacemaker, biostimulator, etc.);
• •5. Pregnant women;
• •6. Pregnancy or breastfeeding;
• •7. Have participated in other clinical trials related to this project within the past 30 days;
• •8. Those who have received stem cell therapy;
• •9. Poor compliance, or can not correctly understand the cooperation so that it can not complete the interview;
• •10. Received intervertebral disc interventional therapy within the past 3 months, such as radiofrequency, laser ablation, protease injection, Ozone injection;
• •11. Highly allergic or have a history of severe allergies;
• •12. Patients with severe autoimmune disease or who are receiving immunosuppressive therapy;
• •13. Serious uncontrolled infection or high fever;
• •14. Patients with shock, failure of vital organs and unstable vital signs;
• •15. X-ray showed that the degree of stenosis of the diseased segment was more than 30% compared with the adjacent normal segment;
• •16. Imaging showed lumbar disc herniation complicated with calcification;
• •17. Imaging showed lumbar disc herniation with Modic Change;
• •18. Imaging showed lumbar disc herniation complicated with severe spinal stenosis;
• •19. Imaging showed lumbar disc herniation complicated with lumbar spondylolisthesis;
• •20. Imaging showed lumbar disc herniation combined with spinal deformity;
• •21. Mental disorders, cognitive disorders, or other physical diseases affecting the research results;
• •22. Doctors believe that there are other reasons for not being included in the treatment.