a PRagmatic Observational Study of Congestion proFILes in patiEnts With Acute Heart Failure

Objective: to study the prevalence of distinct congestion phenotypes and investigate their association with response to therapy and outcomes in acute heart failure patients. Study design: Observational, prospective study Study population: 270 patients admitted with the primary diagnosis of acute heart failure requiring intravenous loop diuretics. Main study parameters/endpoints: To identify distinct congestion phenotypes and study their association with response to therapy and outcomes Secondary outcomes: total natriuresis after 24 hours, and first occurrence of all-cause mortality or heart failure rehospitalisation at 6 months Exploratory outcomes include: length of hospital stay, congestion at discharge and changes in filling pressures over time. Furthermore, as part of the GLYCO-AHF substudy: the expression of glycosaminoglycans and, as part of the PREACH-AHF substudy: the effects of peripheral venous congestion and endothelial dysfunction on a large screen of plasma proteins.