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RECRUITINGPhase 1NCT06585462

Single and Multiple Ascending Dose Study of AMG 513 in Participants With Obesity

The primary objective of this study is to assess the safety and tolerability of AMG 513 after single and multiple doses.

Lead sponsor: Amgen•5 U.S. locations•View source on ClinicalTrials.gov

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Contacts

Amgen Call Center

CONTACT

866-572-6436 medinfo@amgen.com

Sponsors

Lead Sponsor

Amgen

Age

18 - 65 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Participants in the study will be males and females 18 to 65 years of age at the time of signing the informed consent with a body mass index (BMI) of 30.0 kg/m\^2 to 40.0 kg/m\^2 for Part A and BMI of 27.0 kg/m\^2 to 40.0 kg/m\^2 for Part B.
•Females enrolled must be of non-childbearing potential.

Exclusion Criteria

•History and/or clinical evidence of diabetes mellitus, including hemoglobin A1c ≥ 6.5% and/or a fasting glucose of ≥ 126 mg/dL (7 mmol/L) at screening.
•Triglycerides ≥ 5.65 mmol/L (i.e., 500 mg/dL) at screening.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: February 13, 2026Terms

Trial snapshot

StatusRECRUITING

PhasePHASE1

Enrollment80

Start dateSep 2024

Last updatedFeb 13, 2026

Condition

Cardiometabolic Disease

Locations shown

Anaheim Clinical Trials

Anaheim, California

Carilion Medical Center

Lake Forest, California

Fomat Medical Research

Oxnard, California

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: February 13, 2026Data synced to Clareo: May 10, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions