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Interest of Lidocaine in Children with Upper Airway Infection Undergoing General Anesthesia

Lidocaine in Children with Upper Airway Infection Undergoing General Anesthesia: Interventional Controlled Randomized Double Blind Study

NCT06584461•Tunis University

View on ClinicalTrials.gov

Summary

The goal of this clinical trial is to determine whether intravenous (IV) lidocaine reduces the incidence of perioperative respiratory complications (PRCs) in children with upper respiratory tract infections undergoing general anesthesia. The study will also evaluate the safety of IV lidocaine in this population. The main questions it aims to answer are: 1. Does IV lidocaine lower the incidence of perioperative respiratory complications (e.g., laryngospasm, cough, desaturation) compared to a placebo? 2. What are the side effects associated with the administration of IV lidocaine in these children? Researchers will compare IV lidocaine to a placebo to assess its effectiveness in reducing PRCs.

Eligibility

Age

1 - 14 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Children aged 1 to 14 years.
•American Society of Anesthesiologists (ASA) Physical Status Classification I, II, or III.
•Scheduled or urgent surgery or radiological exploration under general anesthesia.
•Upper respiratory tract infection (URTI) symptoms present for less than 15 days.

Exclusion Criteria

•Refusal of participation by parents.
•Children on long-term corticosteroid or bronchodilator therapy.
•Contraindications to the use of lidocaine or other drugs used in the protocol.
•Patients who did not adhere to the study protocol.

Locations (1)

Bechir Hamza Children's Hospital

Tunis, Tunisia

Key Dates

Start Date

January 2, 2023

Primary Completion Date

December 31, 2023

Completion Date

February 5, 2024

Last Updated

September 19, 2024

Enrollment

102

ACTUAL participants

Conditions

Upper Respiratory Tract InfectionsPerioperative Respiratory Complications

Interventions

Lidocaine (drug)

DRUG

Saline (NaCl 0,9 %) (placebo)

DRUG

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Acute Respiratory InfectionViral Infection+1 more

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: September 19, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Interest of Lidocaine in Children with Upper Airway Infection Undergoing General Anesthesia

Inclusion Criteria

Exclusion Criteria

Rapid Diagnosis of Viral Acute Respiratory Infection to Decrease Unnecessary Antibiotic Utilization in the Emergency Department (RADIATE)

A Clinical Study to Determine if Beta Glucan Reduces the Incidence, Duration or Severity of URTIs Among Skiers

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