ASSESS ALL ALS Study

Exclusion Criteria

• •1. Significant cognitive impairment, clinical dementia, or unstable psychiatric illness, including psychosis, active suicidal ideation, suicide attempt, or untreated major depression \<= 90 days of screening, that would interfere with the study procedure, according to Investigator's judgement.
• •2. Clinically significant unstable medical condition (other than ALS) (e.g., cardiovascular instability, systemic infection, untreated thyroid dysfunction, malignant and potentially progressive cancer) that would render the participant unlikely to be able to complete 12 months of follow-up, according to Investigator's judgment.
• •1. Medically unable to undergo lumbar puncture (LP) as determined by the site investigator (i.e., bleeding disorder, a skin infection at or near the LP site, known or suspected intracranial or intraspinal tumor or other cause of increased intracranial pressure).
• •2. Allergy to Lidocaine or other local anesthetic agents.
• •3. Use of anticoagulant medication or antiplatelet medications (aside from aspirin 81 mg) that cannot be safely withheld prior to lumbar puncture.
• •4. Blood dyscrasia, abnormal bleeding diathesis, or the use of dialysis for renal failure.
• •5. Current pregnancy based on participant self-report
• •6. Clinical judgement of the site investigator that the participant would be unable to undergo multiple lumbar punctures.