Study to Assess Monoclonal B-Cell Lymphocytosis in Individuals With Chronic Hepatitis C

PRIMARY OBJECTIVES: I. To determine the prevalence of MBL in patients with chronic hepatitis C who are to begin therapy with directly acting antiviral (DAA), and compare with clinic controls who are seen in the general medicine clinic at Mayo Clinic. II. To determine the correlation between the specific subtype of MBL (CD5- MBL, atypical CLL-phenotype MBL and CLL-phenotype MBL) relative to the hepatitis C virus (HCV) genotype. III. To assess the proportion of individuals with MBL who have an improvement in the circulating monoclonal B-cell population following therapy with DAA. OUTLINE: This is an observational study. Patients undergo blood sample collection and have medical records reviewed throughout study.