Christian Sohns, MD

CONTACT

Astrid Kleemeyer

CONTACT

Lead Sponsor

Heart and Diabetes Center North-Rhine Westfalia

Age

18 - 99 years

Sex

ALL

Healthy Volunteers

No

•1. Ischemic cardiomyopathy with left ventricular ejection fraction ≤ 35% (measured in the last 6 weeks prior to enrollment)
•2. Eligible for heart transplantation due to end-stage heart failure
•3. NYHA class ≥ III
•4. Impaired functional capacity or inability to exercise
•5. Indication for ICD therapy due to primary prevention
•6. Implanted ICD or ICD implantation within 3 months after randomization
•7. The patient is willing and able to comply with the protocol and has provided written informed consent
•8. Age ≥ 18 years

•1. Previous catheter ablation for ventricular arrhythmias
•2. Previous appropriate ICD-therapy for ventricular arrhythmias
•3. Acute coronary syndrome, cardiac surgery, angioplasty, or cerebrovascular accident within 4 weeks prior to enrollment
•4. Untreated hypothyroidism or hyperthyroidism
•5. Woman currently pregnant, breastfeeding, or not using reliable contraceptive measures during fertility age
•6. Mental or physical inability to participate in the study
•7. Listed as "high urgent" for heart transplantation
•8. Cardiac assist device implanted
•9. Planned cardiovascular intervention
•10. Life expectancy ≤ 12 month
•11. Uncontrolled hypertension
•12. Requirement for dialysis due to end-stage renal failure