Clinical and Molecular Features of Oral Premalignancy and Oral Cancer

Primary objectives: Current primary objectives need revision as they focus on diabetes which is not the focus of this study. * Investigators will examine the role of clinical, environmental, and genetic factors in increasing the risk of developing oral cancers and aggressive oral cancers. * To identify important environmental and clinical factors contributing to the risk of developing oral cancer or cancer progression * To identify genetic and molecular factors which contribute to increased risk of developing oral cancers through analysis of germline and somatic genetic alterations * Investigators will identify clinical and molecular predictors of diagnosis, treatment response, toxicity, and outcomes in patients with oral tumors. * To identify and validate clinical and molecular prognostic markers that may predict a patient's response to treatment * To identify and validate clinical and molecular prognostic markers that may predict a patient's risk of developing toxicity related to various modalities of treatment including but not limited to: targeted therapy, chemotherapy, radiation, surgery, and immunotherapy * To identify and validate clinical and molecular prognostic markers that may predict a patient's prognosis * To determine whether clinical and treatment factors influence patients' quality of life as assessed by validated self-report instruments routinely incorporated into clinical care pathways * To identify and validate molecular markers that may improve the diagnosis of oral premalignant or malignant tumors * To characterize acute and long-term function and quality of life after curative treatment(s)