Loading clinical trials...

SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization | Clinical Trials | Clareo Health

ACTIVE_NOT_RECRUITINGNA

SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization

NCT06550024•CrannMed

Summary

An open label, prospective, two-arm, multicenter, randomized controlled trial comparing SakuraBead genicular artery embolization (GAE) with a control (corticosteroid injection).

Detailed Description

To compare safety and efficacy of SakuraBead with corticosteroid injection for the treatment of pain secondary to knee osteoarthritis. Treatment will be performed on a total of approximately 89 patients who will be followed up for a period of 2 years.

Eligibility

Age

40 - 79 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•1. Subject is able and willing to provide written informed consent, and
•2. Clinical diagnosis of knee OA, and
•3. Moderate to severe knee pain (WOMAC Pain ≥ 10), and
•4. Pain refractory to at least 3 months of conservative therapies (anti-inflammatory drugs, or physical therapy, or intra-articular injections), and
•5. Kellgren-Lawrence grade 1, 2 or 3 on radiograph of the knee, and
•6. Age ≥ 40 years and \< 80 years, and
•7. Able to comply with all treatments and follow-up visits.

Exclusion Criteria

•1. Severe knee OA (Kellgren-Lawrence grade 4), or
•2. Current infection of target joint, or
•3. Life expectancy less than 36 months, or
•4. Known advanced atherosclerosis as defined by history of lower extremity or pelvis arterial bypass graft, lower extremity or pelvis arterial stent placement or prior history of vascular claudication, or
•5. Rheumatoid or known serologic diagnosis of autoimmune arthritis, or
•6. Prior knee replacement surgery in the target knee, or
•7. Pain score of \>3 NRS on the non-target knee, or
•8. An acute internal derangement of the target knee, or
•9. History of uncorrectable coagulopathy, or
•10. Prior iodinated contrast reaction resulting in anaphylaxis, or
+4 more criteria

Locations (8)

University of Alabama Medicine

Birmingham, Alabama, United States

Harbor UCLA Medical Center

Torrance, California, United States

Advanced Vascular Institute

Panama City, Florida, United States

IR Centers

Raleigh, North Carolina, United States

IR Centers

Leesburg, Virginia, United States

Bokhua Memorial Cardiovascular Center

Tbilisi, Georgia

Royal Berkshire NHS Foundation Trust

Reading, United Kingdom

Nano Medical Clinic

Tashkent, Uzbekistan, Uzbekistan

Key Dates

Start Date

November 28, 2024

Primary Completion Date

October 1, 2026

Completion Date

October 1, 2028

Last Updated

March 18, 2026

Enrollment

ESTIMATED participants

Conditions

Osteo Arthritis KneeJoint DiseasesMusculoskeletal DiseasesRheumatic DiseasesArthritisOsteoarthritis

Interventions

SakuraBead Resorbable Microspheres

DEVICE

Corticosteroid Injection

DRUG

Comparison of Ultrasound-Guided Injection With Median Nerve Decompression Surgery in Carpal Tunnel Syndrome

NCT06243848

Musculoskeletal DiseasesMedian Nerve Disease+3 more

View study

RECRUITING

The Relationship Between Ultrasonographic Findings and Sleep Quality in Carpal Tunnel Syndrome

NCT05742776

Musculoskeletal DiseasesMedian Nerve Disease+3 more

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 18, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

SakuraBead Used as Resorbable Embolic for Genicular Artery Embolization

Inclusion Criteria

Exclusion Criteria

Comparison of Ultrasound-Guided Injection With Median Nerve Decompression Surgery in Carpal Tunnel Syndrome

The Relationship Between Ultrasonographic Findings and Sleep Quality in Carpal Tunnel Syndrome

Total Versus Robotic Assisted Unicompartmental Knee Replacement

IAMABLE: Implementation and Evaluation of an App for Evidence-Based Self-Management Rehabilitation Strategies

The National Musculoskeletal Audit and Research Database

The Effects of AFO Heel Height and Stiffness on Gait