Pharmacokinetics and Safety Profile of a Single Dose GZR4 in Subjects with Renal Impairment

Exclusion Criteria

• •Known or suspected hypersensitivity to trial product
• •Drugs known to affect creatinine clearance including cimetidine within 14 days or 5 half-lives prior to the day of dosing of GZR4 and during this trial
• •Individuals who routinely undergo dialysis or have a history of renal transplantation, hepatorenal syndrome, or acute kidney injury