• Patients with CKD who required and are currently receiving anticoagulation therapy according to the last guidelines, like: Patient was diagnosed with acute DVT, and or pulmonary embolism, and or splanchnic venous thrombosis.
Mechanical heart valve,
Prevention of stroke and systemic embolism in nonvalvular AF with at least one stroke risk factor :
Prior stroke (ischaemic or unknown type), transient ischaemic attack (TIA) or non-central nervous system (CNS) systemic embolism.
Age ≥ 75 years.
Hypertension. iv. Diabetes mellitus.
Heart failure and/ or left ventricular EF ≤ 35%.
* Patients with CKD ( maintenance or not on hemodialysis)
* Willing and agreed to be included in the study
You may not be if
• Significant inherited or acquired bleeding disorder
* Patient with family history of bleeding tendency
* Patient with contraindication to use anticoagulants
Clinically significant active bleeding
Hepatic disease with associated coagulopathy including Child-Pugh C
Lesions or conditions at significant risk of bleeding including intracranial hemorrhage unless under the advice of a neurologist/neurosurgeon
* Pregnancy, and lactating patient or suspected of pregnancy,
