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Harm Reduction for Smokers With Mental Illness | Clinical Trials | Clareo Health

RECRUITINGNA

Harm Reduction for Smokers With Mental Illness

Harm Reduction for Smokers With Mental Illness: RCT of E-cigarette Provision With or Without Behavioral Support to Boost Switching

NCT06543407•Dartmouth-Hitchcock Medical Center

View on ClinicalTrials.gov

Summary

To compare the efficacy of e-cigarette (e-cig) provision with or without behavioral support (SWITCH IT) delivered via telehealth to reduce harm among smokers with MI who cannot quit smoking and are not ready to pursue cessation treatment, and to examine self-regulation (using e-cigs instead of cigarettes to cope with stress/distress and self-efficacy) as a potential mechanism for behavior change from SWITCH IT

Eligibility

Age

21 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•Diagnostic Criteria (must have one to be eligible):
•Schizophrenia
•Bipolar disorder
•Major Depressive Disorders
•Posttraumatic disorder
•Other anxiety disorders
•21 years or older;
•English-speaking;
•Daily smoker (at least 10 cigarettes/day);
•At least one quit attempt in the past 5 years using evidence- based pharmacotherapy or behavioral cessation support;
+1 more criteria

Exclusion Criteria

•Currently residing in a nursing home;
•Current diagnosis of Asthma;
•Cognitive impairment (score \<26 on the Telephone Interview for Cognitive Status (TICS);
•Current use of e-cigarettes (\>once a week);
•Psychiatric instability (hospitalized in the past month);
•Current AND moderate to severe substance use disorder;
•Pregnant or planning to become pregnant;
•Use of any smoked products other than cigarettes;
•Current unstable medical illness making e-cigarette unsafe (e.g., recent heart attack, cancer);
•Participation in SWITCH IT pilot study.

Locations (2)

Seven Counties Services

Louisville, Kentucky, United States

The Providence Center

Providence, Rhode Island, United States

Key Dates

Start Date

October 1, 2024

Primary Completion Date

December 31, 2027

Completion Date

March 31, 2028

Last Updated

January 15, 2026

Enrollment

250

ESTIMATED participants

Conditions

Tobacco Dependence

Interventions

SWITCH IT

BEHAVIORAL

E-cig Provision Only

OTHER

Contacts

Meghan M. Santos, MSW

CONTACT

978-494-4260 meghan.m.santos@hitchcock.org

Gail Williams, MS, MFT

CONTACT

gail.williams@dartmouth.edu

Effect of Yoga on Reducing Craving in Tobacco Dependent Individuals

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Tobacco Dependence

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RECRUITINGPHASE2

Cannabidiol for Reducing Cigarette Use

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Tobacco Use DisorderTobacco Smoking+1 more

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ACTIVE_NOT_RECRUITINGNA

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: January 15, 2026Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Harm Reduction for Smokers With Mental Illness

Inclusion Criteria

Exclusion Criteria

Effect of Yoga on Reducing Craving in Tobacco Dependent Individuals

Cannabidiol for Reducing Cigarette Use

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DBT for Smoking Cessation in High Risk Veterans