A Study to Find a Suitable Dose of BI 765883 and to Test Whether it Helps People With Advanced Pancreatic Cancer When Taken Alone or Together With Chemotherapy

Exclusion Criteria

• •1. Previous exposure to trial drug (BI 765883)
• •2. Any prior gemcitabine and/or paclitaxel therapy (for combination therapy cohorts)
• •3. Known hypersensitivity to the study medications or their excipients (including gemcitabine and nab-paclitaxel)
• •4. Any contraindications to gemcitabine or nab-paclitaxel according to the current approved local labels (combination therapy)
• •5. Currently enrolled in another investigational device or drug trial, or less than 28 days since ending another investigational device or drug trial(s) or receiving other investigational treatment(s)
• •6. Any serious concomitant disease or medical condition affecting compliance with trial requirements or which are considered relevant for the evaluation of the efficacy or safety of the trial drug, such as neurologic, psychiatric, infectious disease, active ulcers (gastrointestinal tract, skin), inflammatory bowel disease or bowel infection, or laboratory abnormality that may increase the risk associated with trial participation or trial drug administration, and in the judgment of the Investigator, would make the patient inappropriate for entry into the trial.
• •7. Prior radiotherapy or systemic therapy within 14 days prior to treatment start