Age

18–65

Sex

ALL

Healthy volunteers

Not accepted

1. Aged 18-65
2. diagnosed with Schizophrenia, Bipolar Disorder or Major depressive disorder.
3. For Bipolar and Major depressive disorder, Hamilton Depression Rating Scale scores \>8
4. Multimodal 3 T MRI acquisition available (\*)
5. Genetic and serum inflammatory data available, or serum and whole blood available for genotyping and inflammatory markers determination.

1. Presence of major medical or neurological disorders
2. Alcohol or drugs abuse or dependence
3. Conditions known to alter immune-inflammatory status, such as rheumatic diseases, malignancies,
4. ongoing treatment with drugs acting on the immune system, such as corticosteroids, NSAIDs and other immunomodulatory drugs.
5. Pregnancy or lactating

A Biological Signature for the Early Differential Diagnosis of Psychosis