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A Randomized Controlled Trial of Ziyin-Xiehuo Chinese Medicine Herbs Combined With Intradermal Acupuncture for the Treatment of Girl's Idiopathic Precocious Puberty With Yin Deficiency and Fire Hyperactivity
A randomized controlled study will be conducted to evaluate the therapeutic effect of traditional Chinese medicine and acupoints stimulation on children with idiopathic precocious puberty.
Traditional Chinese medicine is effective for precocious puberty which is mild or moderate, but not effective for the one that is severe and rapidly progressing. Acupuncture can effectively regulate sex hormone levels and ovarian function, promote ovulation, and have therapeutic effect for polycystic ovary syndrome and irregular menstruation. Studies have shown that acupuncture and auricular point compression stimulation is effective for premature thelarche, yet there are few studies on idiopathic precocious puberty. Clinical evidence is still needed to support whether acupuncture point stimulation combined with traditional Chinese Medicine herbs can enhance the effect and prevent the progression into severe or rapidly progressing precocious puberty, hence the study is to be carried out.
Age
4 - 9 years
Sex
FEMALE
Healthy Volunteers
No
Children's Hospital of Fudan university
Shanghai, Shanghai Municipality, China
Children's Hospital of Fudan University
Shanghai, China
Start Date
September 15, 2024
Primary Completion Date
July 1, 2027
Completion Date
July 1, 2027
Last Updated
March 16, 2026
170
ESTIMATED participants
intradermal needles
OTHER
Ziyinxiehuo Granules of traditional Chinese Medicine
DRUG
Lead Sponsor
Children's Hospital of Fudan University
NCT05292664
NCT07462065
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