Effects Of Vitamin D On Bone, Muscle, And Adipose Tissue In Obese Subjects

Exclusion Criteria

• •eGFR \<40 ml/min/1.72 m2 by EPI formula (21);
• •hypercalcemia (\>10.5 mg/dL);
• •osteoporosis (hip or vertebral t-score \>-2.5);
• •conditions affecting bone
• •vitamin D and/or calcium metabolism (chronic liver disease, renal failure, malabsorption, hypercortisolism);
• •medications altering bone metabolism (e.g. denosumab, bisphosphonates, teriparatide, glucocorticoids, aromatase inhibitors, estrogen);
• •enrollment in an interventional clinical trial in the previous 3 months.