Setting up a Cohort of Patients With Inflammatory Bowel Disease and a Cohort of Patients Without Chronic Inflammatory Bowel Disease

Inclusion Criteria

• •General criteria:
• •Male or female ≥ 18 years old
• •Able to follow the instructions of the study
• •Having signed an informed consent
• •Specific for Crohn cohort:
• •A confirmed diagnosis of IBD
• •Rectal or colonic or ileocolic involvement
• •Patients with CD presenting inflammatory flare and disease extent in the colon or ileocolic region with:
• •A clinical activity defined by an average of four or more instances of very soft or liquid stools daily or an abdominal pain score of 2 or more OR a CDAI (CD Activity Index) ≥ 220 OR a Harvey-Bradshaw Index \> 8 OR a faecal calprotectin ≥ 250 µg/g And
• •A endoscopic activity defined by a SES-CD (Simple Endoscopic Score for Crohn Disease) ≥ 6 or a CDEIS (CD Endoscopic Index score) ≥ 7
• •Patients with UC presenting inflammatory flare with:
• •A clinical activity defined by a modified Mayo score ≥ 3 OR a Simple Clinical Colitis Activity Index ≥5 OR Patient Reported Outcome (PRO2) ≥ 4 with a subscore of rectal bleeding ≥1 OR a faecal calprotectin ≥ 250 µg/g AND An endoscopic activity defined by a Mayo endoscopic sub-score ≥ 2
• •Specific for Control cohort:
• •Patient with no colonic lesion(s) visible during the endoscopical examination (neither Crohn's nor other colitis nor cancer)