Efficacy and Safety of memanTine in the Treatment Of Frequently symPtomatic Atrial Premature Beats

Exclusion Criteria

• •1. Atrial fibrillation, atrial flutter, or persistent atrial tachycardia (confirmed by electrocardiogram within the past 6 months or detected by continuous 3-day (72h) monitoring with a wearable Holter monitor at baseline); or ventricular tachycardia (excluding occasional short episodes of ventricular tachycardia during sleep) or ventricular fibrillation.
• •2. Occurrence of a stroke event, including hemorrhagic/ischemic stroke and transient ischemic attack (TIA), within the past 6 months prior to screening; history of cardiac surgery, myocardial infarction (MI), percutaneous coronary intervention (PCI), or atrial arrhythmia radiofrequency ablation within the past 3 months prior to screening.
• •3. Left ventricular ejection fraction (LVEF) ≤40%; or New York Heart Association (NYHA) functional class III or IV.
• •4. Sick sinus syndrome, second-degree type II or higher atrioventricular block, or bifascicular block without permanent pacemaker implantation.
• •5. Ongoing use of amiodarone within the past 4 weeks prior to screening, or ongoing use of antiarrhythmic drugs other than amiodarone, as well as Chinese herbal medicine with antiarrhythmic effects within the past 1 weeks prior to screening.
• •6. Presence of unstable angina, severe congenital heart disease (excluding patent foramen ovale), post-artificial heart valve replacement, acute myocarditis, acute endocarditis, rheumatic heart valve disease,Hypertrophic obstructive cardiomyopathy.
• •7. Coexistence of other diseases with an expected survival period of less than 1 year.
• •8. Active hepatitis or significant liver dysfunction (ALT or AST \>3 times the upper limit of normal \[ULN\], TBIL \>3 ULN).
• •9. Severe renal insufficiency (calculated estimated glomerular filtration rate \[eGFR\] \<40 ml/min/1.73m² using the CKD-EPI equation).
• •10. Received investigational drugs or medical device treatments in other clinical trials within 1 month prior to screening or within 5 half-lives (whichever is longer).
• •11. Pregnancy, lactating women, or positive pregnancy test result before randomization.
• •12. Hyperthyroidism that has not been properly treated and thyroid function has not returned to normal, the perioperative period of cardiothoracic surgery (one week before surgery to two weeks after surgery), uncorrected electrolyte disturbances (serum K+ \> 5.5 mmol/L or \< 3.5 mmol/L, serum magnesium \< 1.5 mmol/L, etc.); chronic obstructive pulmonary disease (COPD) combined with respiratory failure or infection that has not been corrected, etc.
• •13. History of epilepsy, seizures, or mental illness.
• •14. Known allergy to memantine hydrochloride tablets or their excipients.
• •15. Patients currently receiving memantine treatment for moderate or severe Alzheimer's disease.
• •16. Other circumstances where the investigator deems the subject unsuitable for inclusion in the study.