Combination Therapy of 5-Fluorouracil and CALcipotriol Versus 5-Fluorouracil in the Treatment of Actinic Keratosis

Exclusion Criteria

• •Previous field treatment for AK within 2cm of the treatment area, within 3 months
• •(non) melanoma skin cancer in treatment area
• •Mucosal lesions
• •Genetic skin cancer disorder
• •Women who are pregnant or breastfeeding
• •Women of childbearing potential, who are not willing to use effective contraceptive measures
• •Previous allergy or intolerance to either 5FU or calcipotriol
• •Patients with known contra-indications for calcipotriol use: previous diagnosis of hyper-calcemia, disturbed calcium metabolism, severe kidney or liver dysfunction
• •Concurrent use of oral capecitabine or any other topical or systemic chemopreventive agent for any indication
• •Concurrent use of other topical treatments registered as treatment for AK
• •Limited understanding of the Dutch language and not being able to give informed consent (incapacitated patients)