Fundacio d'Investigacio en Atencio Primaria Jordi Gol i Gurina
With
Institut Català de la Salut
Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
\- Adults (≥18) candidates for preventive treatment for migraine; those with a frequency of ≥4 monthly migraine days, and who agree to participate in the clinical trial.
You may not be if
People diagnosed with migraine who are not candidates for preventive migraine treatment
People diagnosed with chronic migraine (\>15 days of headache per month, of which 8 are monthly migraine days)
Not having a smartphone
Simultaneous participation in another clinical trial
Pregnancy or expected pregnancy during the next 3 months
Lactation
People with migraine who already receive preventive treatment.
People on chronic treatment with opioids or other analgesics or NSAIDs that are not used for the symptomatic treatment of migraine, for example, osteoarthritis.
People who, in the opinion of the clinician, have an absolute contraindication to one of the study drugs or who cannot perform the trial procedures:
Hypersensitivity to any of the study drugs / Heart block or severe bradycardia / Concomitant treatment with verapamil or diltiazem / Active cardiovascular pathology (recent heart attack, angina, Raynaud's phenomenon) / Major depression or active treatment with antidepressants (including monoamine oxidase inhibitors and St. John's wort) / Other psychiatric illnesses or active treatment with antipsychotics or lithium / Severe liver disease or kidney failure / Parkinson's disease or other extrapyramidal disorders / Epilepsy (diagnosis and/or active treatment) / Any other contraindication that, in the opinion of the clinician, prevents participation in the clinical trial
