Polyspecific Antibodies in Lymphoproliferative T-cell Disorders

Exclusion Criteria

• •1. Is diagnosed with a bulky disease (≥10 cm).
• •2. Has known history or presence of central nervous system involvement by leukemia or lymphoma.
• •3. Has Mature T-cell and NK-cell leukemias (WHO 2022 criteria)
• •4. Has T-lymphoblastic leukemia/lymphoma (WHO 2022 criteria)
• •5. Has tumor-like lesions with T-cell predominance (WHO 2022 criteria)
• •6. Has Primary cutaneous T-cell lymphomas (WHO 2022 criteria)
• •7. Has any other active cancers, or history of treatment for invasive cancer ≤3 years.
• •Note: Participants with stage I cancer who have received definitive local treatment at least 3 years previously and are considered unlikely to recur are eligible. All participants with previously treated in situ carcinoma (i.e., non-invasive) are eligible.
• •8. Received any of the following treatments prior to the first dose of study medication:
• •* Systemic chemotherapy, targeted small molecule therapy, or radiation therapy within 4 weeks (or 5 half-lives, whichever is shorter) before Cycle 1 Day 1. Participants that received local radiation therapy are eligible.
• •* Therapeutic anti-cancer antibodies \<4 weeks
• •* Any investigational drug in the last 4 weeks prior
• •* Any major surgery or immunotherapy within 28 days
• •* Toxin immunoconjugates \<4 weeks
• •* Nitrosoureas \<6 weeks
• •* Allogeneic hematologic stem cell transplant within 3 months
• •* Adaptive cellular therapy such as autologous or donor natural killer cell or T lymphocyte infusions within 90 days
• •* Systemic corticosteroids (prednisone or equivalent \>10 mg daily) within 2 weeks prior to the start of therapy, or 12 weeks if given to treat graft versus host disease (GVHD), except for physiological replacement doses of cortisone acetate or equivalent
• •* Systemic treatment for GVHD (including but not limited to oral or parenteral corticosteroids, ibrutinib, and extracorporeal phototherapy) within the last 12 weeks
• •9. Is experiencing a toxicity (or AE) from prior anti-cancer treatment that has not resolved to Grade ≤1 or baseline.
• •10. Has a known infection with human immunodeficiency virus (HIV) or serologic status reflecting active hepatitis B or C infection as follows:
• •* Presence of hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb). Participants with presence of HBcAb, but absence of HBsAg, are eligible only if hepatitis B virus (HBV) DNA is undetectable by an assay with sensitivity \<20 IU/mL. If so, participants may either undergo regularly scheduled monitoring of HBV DNA or less frequent monitoring of HBV DNA while on prophylactic antiviral medication as defined by regional standard of care.
• •* Presence of hepatitis C virus (HCV) antibody. Participants with presence of HCV antibody are eligible only if HCV RNA is undetectable.
• •11. Has a known active tuberculosis infection.
• •12. Has an active fungal, bacterial, and/or viral infection requiring systemic therapy.
• •13. Had a vaccination with a live vaccine within 35 days prior to the first dose of LIS1.
• •14. If woman, is pregnant or nursing a child.
• •15. Has an active autoimmune disease or history of autoimmune disease that may relapse except for type I diabetes under control, hypothyroidism managed with hormone replacement therapy, controlled celiac disease, and skin disease (vitiligo, psoriasis, etc.) not requiring systemic treatment.
• •16. Has a known history of interstitial lung disease, non-infectious pneumonitis, pulmonary fibrosis, acute lung disease, or dyspnea at rest or pulse oxymetrie \< 92% at room air.
• •17. Has a clinically significant cardiovascular disease including the following:
• •* Myocardial infarction or unstable angina within 3 months before screening
• •* Congestive heart failure (New York Heart Association functional classification III-IV)
• •* History of clinically significant arrythmias
• •* QTcF \> 470 msec
• •* History of Mobitz II second degree or third-degree heart block without a permanent pacemaker in place
• •* Uncontrolled hypertension as indicated by a minimum of 2 consecutive blood pressure measurements showing systolic blood pressure \>170 mm Hg and diastolic blood pressure \>105 mmHg at screening
• •18. Has a cognitive impairment, active substance abuse, or psychiatric illness or social situations that, in the view of the Investigator, would preclude safe treatment or the ability to give informed consent and limit compliance with study requirements.
• •19. Has a known history of drug-induced liver injury, alcoholic liver disease, non- alcoholic steatohepatitis, primary biliary cirrhosis, ongoing extrahepatic obstruction caused by stones, cirrhosis of the liver or portal hypertension.
• •20. Has a hemophilia or von Willebrand's disease.
• •21. Has any psychological, familial, sociological, or geographical conditions that do not permit compliance with the protocol.
• •22. Has a concurrent condition that, in the Investigator's opinion, would jeopardize compliance with the protocol.
• •23. Are unable or unwilling to comply with study and/or follow-up procedures outlined in the protocol.
• •24. For France, participants under legal protection (safeguard, guardianship, curatorship).
• •25. Is currently participating in another therapeutic clinical study.
• •26. Has a known hypersensitivity to polyclonal antibody.