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RECRUITINGNA

Task Practice and Spinal Cord Stimulation

Task Practice Combined With Transcutaneous Spinal Cord Stimulation to Reduce Muscle Co-contraction and Improve Motor Function in Chronic Spinal Cord Injury

NCT06494020•University of Miami

View on ClinicalTrials.gov

Summary

The goal of this study is to understand the effects of combined task practice with transcutaneous cervical spinal cord stimulation. The study will explore the effect of higher stimulation frequencies on spasticity. Transcutaneous stimulation has been shown to improve motor function in some individuals with chronic spinal cord injury. The study intends to explore scientifically the association between higher stimulation frequencies and spasticity/hypertonicity.

Eligibility

Age

22 - 70 years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•22-70 years of age
•Non-progressive cervical spinal cord injury
•Minimum 12 months year post-injury.
•American Spinal Injury Association (ASIA) Impairment Scale (AIS) classification B, C, or D.
•Able to take part in upper extremity therapy procedures.
•GRASSP-Prehension score ≥10.
•MAS Score ≥3 but \<6 in at least one arm.
•Can commit to the time required for the study.
•Stable medication profile for at least 4 weeks prior to enrollment.
•Able to reduce Baclofen dose to 30 mg or less daily.
+1 more criteria

Exclusion Criteria

•Has any unstable or significant medical condition that is likely to interfere with study procedures like severe neuropathic pain, depression, mood disorders, or other cognitive disorders.
•Has uncontrolled cardiopulmonary disease or cardiac symptoms.
•Requires ventilator support.
•Has been diagnosed with autonomic dysreflexia that is severe, unstable, and uncontrolled.
•Has an autoimmune etiology of spinal cord dysfunction/injury
•Previously diagnosed as having transverse myelitis
•History of additional neurologic diseases such as stroke, multiple sclerosis, traumatic brain injury, epilepsy or history of seizures.
•Peripheral neuropathy (diabetic polyneuropathy, entrapment neuropathy, etc.)
•Uncontrolled spasms, which have been unstable over the past three months prior to enrollment and are not expected to change.
•Received Botulinum toxin injections in their upper extremity, neck, or hand within six months prior to enrollment.
+9 more criteria

Locations (2)

University of Miami - Christine E. Lynn Rehabilitation Center

Miami, Florida, United States

University of Miami, Miller School of Medicine, The Miami Project To Cure Paralysis

Miami, Florida, United States

Key Dates

Start Date

September 1, 2024

Primary Completion Date

October 1, 2027

Completion Date

October 1, 2027

Last Updated

August 19, 2025

Enrollment

ESTIMATED participants

Conditions

Spinal Cord Injury CervicalSpastic

Interventions

Task Practice combined with Transcutaneous Spinal Cord Stimulation( TcSCS)

OTHER

Contacts

Nilanjana Datta, MD

CONTACT

3052436798 nx693@med.miami.edu

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

NCT01568658

Muscular DystrophiesMuscle Myopathies+3 more

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RECRUITING

A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monitor Its Development

NCT06055725

Spasticity as Sequela of Stroke

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: August 19, 2025Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Task Practice and Spinal Cord Stimulation

Inclusion Criteria

Exclusion Criteria

Genetic and Physical Study of Childhood Nerve and Muscle Disorders

A Study to Estimate How Often Post-stroke Spasticity Occurs and to Provide a Standard Guideline on the Best Way to Monitor Its Development

Utility of CC7 Transfer in Stroke Subtypes

Restoration of Hand Function in Cervical SCI

A Study to Evaluate the Safety of a Delivery Device for Administering LCTOPC1 in Participants With Spinal Cord Injury

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