A Study of Radiation Therapy After Surgery in People With Oral Tongue Squamous Cell Carcinoma

Inclusion Criteria

• •Age ≥ 18
• •Surgical resection of all gross disease without evidence of residual loco-regional disease on simulation PET/CT.
• •pT1-2, or pT3 by DOI, pN0-2b Squamous Cell Carcinoma of the Oral Tongue confirmed on final surgical pathology. Patients must have:
• •* at least two of the following pathologic risk features
• •* LVI
• •* DOI ≥ 4mm and ≤ 10mm OR
• •* 1 or 2 pathologically positive nodes N1 to low volume N2b. OR DOI \>10 mm OR
• •* \<=cT3N2b who undergo induction with near pCR (\<5% viable) or pCR at primary site
• •Primary specimen surgical margins ≥3 mm (if \<WPOI 5, margin can be \>= 2.2mm)
• •Signed informed consent form by the participant or their legally authorized representative (LAR)