Study of the ETX-4143 2.0 Device in Subjects With Eye Pain

Exclusion Criteria

• •Women who are pregnant, breastfeeding, or planning to become pregnant or breastfeed during the study time period, including the follow-up period
• •Any active ocular infection or active ocular inflammation at the time of the screening visit
• •History of herpes keratitis, non-healing corneal epithelial defects, or neurotrophic keratopathy due to corneal herpetic disease, stem cell deficiency, diabetic keratopathy, severe lagophthalmos, or topical anesthetic abuse
• •Any history of significant eye surgery with the prior 90 days
• •Planned eye surgery during the entire study
• •Participation in any clinical study of an investigational product within 30 days prior to enrollment
• •Any history of serious, poorly controlled systemic or ophthalmic condition that could compromise the subject's ability to comply with the protocol or compromise their safety