RQC for the Prevention of Alzheimer's Disease and Retinal Amyloid-β

Exclusion Criteria

• •MMSE score 0-25, indicating more than subtle cognitive abnormalities
• •CDR-SB score \> 0, indicating functional impairment
• •Clinical diagnosis of any non-Alzheimer's disease (AD) type of mild cognitive impairment (MCI) or dementia
• •Taking pharmaceutical anti-Aβ monoclonal antibodies (i.e., Leqembi, Aduhelm).
• •Participation in another clinical study with an investigational product during the last 90 days.
• •Presence of hepatic disease or kidney disease
• •Clinically significant or unstable hematologic, cardiovascular, pulmonary, gastrointestinal, endocrine metabolic, or other systemic disease.
• •Diagnosis of gastrointestinal or stomach condition including but not limited to irritable bowel syndrome (IBS), ulcerative colitis, peptic ulcers, Crohn's disease, gastroesophageal reflux disease, gastritis, severe dyspepsia, and intestinal malabsorption.
• •Clinically significant abnormal values in hematology, coagulation and platelet function, clinical chemistry, or urinalysis at screening (such as those with prolonged prothrombin time (PT), anemia, low neutrophil or platelet count, elevated liver function tests, low glomerular filtration rate).