Natural History of Depression, Bipolar Disorder and Suicide Risk

Study Description: This proposal would collect systematic data on individuals undergoing personalized treatments for depression, bipolar disorder and suicide risk within the Experimental Therapeutics and Pathophysiology Branch (ETPB). The ETPB recruits individuals with treatment-resistant mood disorders from around the country. After research participation, they are often offered a course of standard treatment, tailored to clinical needs, for clinical stabilization and discharge back to non-NIH clinicians. This protocol would allow for clinical ratings in-person and remotely throughout clinical standard treatments, as well as neurobiological procedures at baseline and study termination to identify potential clinical and demographic predictors and biomarkers of treatment response. Objectives: The primary objective is to identify predictors of antidepressant treatment response. The secondary and tertiary objectives are to identify predictors of suicide ideation response to treatment, and biomarkers of antidepressant response to treatment, respectively. Endpoints: Primary Endpoint: Score on the Montgomery Asberg Depression Rating Scale Secondary Endpoint: Score on the Scale for Suicidal Ideation