A Trial to Learn How Well REGN7508 Works for Preventing Blood Clots After a Knee Replacement in Adult Participants

Exclusion Criteria

• •1. History of bleeding in the past 6 months prior to dosing requiring hospitalization or transfusion; history of intracranial or intraocular bleeding, excessive operative or post-operative bleeding, and traumatic spinal or epidural anesthesia; history of bleeding diathesis
• •2. History of thromboembolic disease or thrombophilia
• •3. History of major surgery, including brain, spinal, or ocular, within approximately the past 6 months
• •4. History of major trauma within approximately the past 6 months prior to dosing
• •5. Hospitalized (\>24 hours) for any reason within 30 days of the screening visit
• •6. Has an estimated glomerular filtration rate (GFR) of \<45 mL/min/1.73m\^2 at the screening visit using one of the following formulas: the Modification of Diet in Renal Disease (MDRD) equation, the Chronic Kidney Disease Epidemiology Collaboration equation, or equivalent equation