Local Liver Treatment for Multi-organ Colorectal Cancer Metastases

Exclusion Criteria

• •Patients with only liver metastasis confirmed by CT or MRI.
• •History of hepatic encephalopathy or liver transplantation.
• •Evidence of brain metastases.
• •Pregnant or breast-feeding women.
• •History of other malignant tumors (except thyroid cancer and carcinoma in situ) can be included in the study if the individual has remained disease-free for at least 5 years.
• •Patients with acute cardiovascular and cerebrovascular diseases such as acute cerebral infarction and acute coronary syndrome within 1 month, and the cardiovascular clinical symptoms or diseases were not well controlled.
• •NYHA class 3-4 or left ventricular ejection fraction (LVEF) \< 50 % by echocardiography.
• •Uncontrollable hypertension, blood pressure \> 160 / 95 mmHg after treatment, history of hypertensive crisis or hypertensive encephalopathy.
• •Uncontrollable infection \> grade 2 (NCI-CTC version 5.0).
• •Patients with respiratory insufficiency : PaO2 \< 60 mmHg at rest , with or without PaCO2 \> 50 mmHg.
• •Patients with a large amount of ascites (ultrasound examination showed an echoless area around the liver and spleen, pelvic cavity, and intestinal loops, and the mesentery and intestinal canal were seen floating in the echoless area ) or malignant ascites (cancer cells were found in ascites or ascites CEA was higher than peripheral blood).
• •Coagulation dysfunction ( INR \> 1.5 or APTT \> 1.5\*ULN ), with bleeding tendency.
• •Long-term unhealed wounds or fractures, major surgery or severe traumatic injury, fracture or ulcer occurred within 4 weeks.
• •Patients with a history of mental drug abuse and who could not quit or had mental disorders.
• •According to the investigator's judgment, patients with concomitant diseases that seriously endanger patient safety or affect patient completion of the study.
• •According to the investigator's judgment, patients who are not suitable for inclusion.