PH Weighted Chemical Exchange Saturation Transfer MRI-Based Surgical Resection to Improve Survival in Patients With Glioblastoma

PRIMARY OBJECTIVE: I. To assess the efficacy of potential of hydrogen (pH) sensitive MRI based resections of glioblastoma. SECONDARY OBJECTIVE: I. To find surgical and adjuvant therapies to treat infiltrating glioblastoma cells. OUTLINE: Patients are randomized to 1 of 2 groups. GROUP I: Patients undergo surgical resection with standard intraoperative guidance using contrast-enhanced MRI. Patients also undergo post operative standard of care radiation therapy over 30 fractions and receive standard of care temozolomide orally (PO) for 6 weeks. Additionally, patients undergo MRI during follow up. GROUP II: Patients undergo surgical resection with intraoperative guidance using CEST MRI. Patients also undergo post operative standard of care radiation therapy over 30 fractions and receive standard of care temozolomide PO for 6 weeks. Additionally, patients undergo MRI during follow up. After completion of study treatment, patients are followed up at months 3, 6, 12, and 24.