OsteoGen Plug vs. Freeze-dried Bone Allograft With Collagen Barrier

Exclusion Criteria

• •Subjects with reported allergy or hypersensitivity to any of the products to be used in the study.
• •Subjects with untreated / active periodontal disease.
• •Subjects with vesiculobullous processes or other similar chronic oral lesions / conditions resulting in gingival irritation, discomfort/pain, or erosions.
• •Tobacco/Cannabis users including cigarettes, vape, cigars, or smokeless tobacco.
• •Uncontrolled medical conditions (e.g., diabetes mellitus, hypertension, cancer)
• •Subjects who are lactating or pregnant or planning to become pregnant through their projected study duration.
• •Subjects who would require a tissue supported interim prosthesis i.e. acrylic / valplast RPD (tooth supported interim prostheses i.e. essix retainers are acceptable)
• •Subjects with long-term history of oral bisphosphonates (\> 10 years).
• •Subjects with a history of intravenous bisphosphonates.
• •Subjects taking medications known to affect gingival conditions. (e.g., hyperplasia)
• •Subjects taking corticosteroids or immunosuppressants on a regular basis prior to baseline examination.
• •Subjects taking anticoagulant medications such as warfarin or Plavix or Eliquis who are not medically cleared to hold medication prior to and during procedure.
• •Subjects participating in other clinical studies involving therapeutic intervention (either medical or dental).
• •Subjects, who in the opinion of the investigator, for any reason other than those listed above, will not be able to complete the study per protocol.