Loading clinical trials...

Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome | Clinical Trials | Clareo Health

COMPLETEDNA

Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome

Outcome Measures of Auto-titrating Average Volume-assured Pressure Support (AVAPS) as Rescue Therapy After CPAP Titration Failure in Patients With Obesity Hypoventilation Syndrome: Adherence and Sleep Quality

NCT06442163•Assiut University

View on ClinicalTrials.gov

Summary

It remains unclear whether CPAP therapy should be prescribed if significant hypoxemia persists during CPAP titration, despite optimization of upper airway obstructive events, if maximum CPAP pressure is reached. The goal was to examine the effects of 6 months of home AVAPS therapy in patients with obesity hypoventilation syndrome as a potential option for patients who failed CPAP titration due to persistent hypoxemia.

Detailed Description

Obesity hypoventilation syndrome (OHS) is one of the leading indications of home non-invasive ventilation (NIV) initiation. In patients with OHS, NIV improves daytime vigilance, decreases PaCO2, improves sleep quality, and improves physical activity. Thus, the primary aim of this study was to evaluate the effects of 6-month noninvasive ventilation with average volume-assured pressure support (AVAPS-AE) ventilation on objective sleep quality and adherence to therapy in stable patients with OHS who failed CPAP titration.

Eligibility

Age

18 - No limit years

Sex

ALL

Healthy Volunteers

Inclusion Criteria

•All Clinically stable OHS patients with
•* Body mass index of 30 kg/m2 ,
•* Daytime hypercapnia (PaCO2 \>45 mm Hg) who had failed to respond to CPAP therapy
•* had no other cause for their chronic respiratory failure and were naive to any PAP therapy.

Exclusion Criteria

•Patients with evidence of acute respiratory failure (patients with worsening symptoms during the last 2 weeks before the screening visit, a breathing frequency of 30 breaths/ minute, or signs of respiratory infections)
•Patients who had been intubated during the last 3 months
•Patients who had received any other form of ventilatory support before hospital admission were also excluded from the study

Locations (1)

Assuit University Hospital

Asyut, Assuit, Egypt

Key Dates

Start Date

May 12, 2020

Primary Completion Date

April 30, 2024

Completion Date

April 30, 2024

Last Updated

June 4, 2024

Enrollment

ACTUAL participants

Conditions

Obesity Hypoventilation Syndrome (OHS)

Interventions

AVAPS study was performed within 1 week of the CPAP titration attempt failure, using the auto-titrating EPAP (AE), the OmniLab Advanced +, System One device (Philips Respironics, Murrysville, PA, U.S.

DEVICE

Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation

NCT06560411

Obstructive Sleep ApneaObesity Hypoventilation Syndrome (OHS)+2 more

View study

COMPLETED

Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome

NCT06983418

Euthyroid Sick SyndromeObesity Hypoventilation Syndrome (OHS)

View study

Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: June 4, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions

Average Volume-assured Pressure Support as Rescue Therapy in Obesity Hypoventilation Syndrome

Inclusion Criteria

Exclusion Criteria

Evaluation of Auto-EPAP for Management of Upper Airway Obstruction During Non-Invasive Ventilation

Euthyroid Sick Syndrome in Obesity Hypoventilation Syndrome

Evaluation of An Optical Measurement Algorithm Combined With Patient and Provider Input to Reduce Mask Exchanges During Initial Positive Airway Pressure Therapy

Response to NonInvasive Mechanical Ventilation According to the Breathing Pattern

Respiratory Muscle Endurance in Obesity Hypoventilation Syndrome