Dynamic ctDNA Detection for Colorectal Cancer Liver Metastases

Inclusion Criteria

• •1. Before implementing any trial-related procedures, written informed consent should be signed;
• •2. \>=20 and \<= 85 years old, male or female;
• •3. Patients with liver metastases pathologically confirmed as colorectal adenocarcinoma;
• •4. According to the Response Evaluation Criteria for Solid Tumors (RECIST version 1.1), there is at least one lesion that can be measured by imaging;
• •5. The multidisciplinary team (MDT) confirmed that the liver metastases were initially resectable ,without locally treatable extrahepatic metastases;
• •6. The general physical condition is good (ECOG score 0-1);
• •7. Life expectancy of more than 3 months;
• •8. There is no obvious symptoms of primary bleeding, obstruction and other indications for emergency surgery;
• •9. adequate organ function;
• •10. samples meet NGS quality control requirements;
• •11. The subjects are able and willing to comply with the visits, treatment plans, laboratory tests and other research-related procedures stipulated in the research protocol.