The Effect of Increasing Dialysate Calcium on T50 in Subjects With Secondary Hyperparathyroidism and ESKD

Inclusion Criteria

• •Age ≥ 18 years.
• •Treatment with thrice-weekly maintenance HD for ESKD for \> 3 months.
• •Dialysate calcium of 1.25 mmol/L (standard concentration).
• •Plasma ionised calcium \< 1.35 mmol/L (average of last 3 months).
• •Plasma intact PTH \> 14 ρmol/L.
• •Plasma total alkaline phosphatase \>90 U/L
• •Negative pregnancy test and use of highly effective and safe contraception.
• •Able to give written informed consent.