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The Efficacy and Safety of Tofacitinib in Patients With Glucocorticoid Resistant ICIs-related Myocarditis | Clinical Trials | Clareo Health

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The Efficacy and Safety of Tofacitinib in Patients With Glucocorticoid Resistant ICIs-related Myocarditis

The Efficacy and Safety of Tofacitinib in Patients With Glucocorticoid Resistant ICIs-related Myocarditis: a Single-arm, Prospective, Phase 2 Trial

NCT06393972•Shanghai Zhongshan Hospital

Summary

The efficacy and safety of Tofacitinib in patients with glucocorticoid resistant ICIs-related myocarditis: a single-arm, prospective, phase 2 trial

Eligibility

Age

18 - 85 years

Sex

ALL

Healthy Volunteers

•1. Age ≥ 18 years old
•2. Patients treated with ICI immunotherapy (monotherapy or combination), including anti-PD1, anti-PDL1, anti-CTLA4; and including any type of cancer (even those in which ICI is not currently approved by regulatory)
•3. Definite, probable or possible ICI-induced myocarditis according to the diagnostic criteria of the most recent expert consensus recommendations (e.g27, to be updated with any new recommendations to be published)
•4. corticosteroid-resistant ICI-myocarditis: Corticosteroid-resistant ICI-myocarditis is defined by the absence of decrease in troponin levels or the appearance/persistence of severity criteria despite receiving prednisone dose ≥0.5 mg/kg/day for ≥2 days.
•5. Signature of informed consent before any trial procedure from the patient or legal representative or the close relative
•6. Patients covered by social security regimen (excepting AME)
•7. Withhold of ICI

•1. Untreated and/or uncontrolled bacterial, fungal, or viral infection Pregnancy, breast-feeding or planning to become pregnant during the study period
•2. For women of childbearing age, lack of effective contraception throughout the duration of participation in the study
•3. Being treated with tofacitinib within 3 months prior to inclusion Known hypersensitivity to abatacept or belatacept
•4. Being treated with anti-thymoglobulin, or alemtuzumab within 6 weeks of the first scheduled dose of abatacept
•5. Patient participating to another interventional study (RIPH 1 only) People under legal protection measure (tutorship, curatorship or safeguard measures)

Key Dates

Start Date

July 1, 2024

Primary Completion Date

November 30, 2025

Completion Date

November 30, 2026

Last Updated

May 1, 2024

Enrollment

ESTIMATED participants

Conditions

Glucocorticoid Resistant ICIs-related Myocarditis

Interventions

Tofacitinib 5 MG BID

DRUG

Contacts

Yan Wang

CONTACT