Biologic Therapy for Generalized Pustular Psoriasis

Exclusion Criteria

• •1. Pregnant and lactating patients.
• •2. Patients with malignant tumors.
• •3. Patients with a history of multiple drug allergies or a severe allergic constitution.
• •4. Contraindications for ustekinumab/secukinumab, including active tuberculosis, active hepatitis B, hepatitis C, or inflammatory bowel disease.
• •Patients who were severely immunocompromised.