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The Effects of Auditory Stimulation During Sleep on Offline Learning and Thalamocortical-hippocampal Connectivity in Schizophrenia
In this research study the investigators will use sleep headbands to measure brain rhythms and to improve their coordination across brain regions. The headbands will be worn at home for multiple nights. On some nights the headbands will play soft sounds at specific times during sleep. The investigators are interested in learning whether this timed auditory stimulation may be a strategy to improve the coordination of sleep rhythms across brain regions, improve network communication, and as a result, improve memory. The investigators will study 30 adults aged 18-45 with schizophrenia and 30 demographically matched healthy controls. Participants will first have a daytime MRI scan, during which they will complete a finger tapping motor sequence task (MST), followed by a week of sleep at home with a sleep headband. They will also do the MST at home on two of the nights. On the final day of the study, participants will return for a second MRI scan.
Age
18 - 45 years
Sex
ALL
Healthy Volunteers
Yes
Massachusetts General Hospital
Charlestown, Massachusetts, United States
Start Date
February 5, 2025
Primary Completion Date
June 30, 2027
Completion Date
December 31, 2027
Last Updated
May 14, 2025
60
ESTIMATED participants
Closed loop auditory stimulation during sleep
OTHER
Lead Sponsor
Massachusetts General Hospital
NCT07455929
NCT06740383
Data Source & Attribution
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