Loading clinical trials...
Loading clinical trials...
Effect of Amobarbital Sodium Combined With Low-dose Propofol on Hemodynamics During Induction and Perioperative Adverse Reactions in Gynecological Laparoscopic Surgery
At present, there are limited data on perioperative efficacy of barbiturates at home and abroad. The purpose of this clinical trial is to observe the effects of amobarbital sodium combined with low-dose propofol on hemodynamics during induction and perioperative adverse reactions in gynecological laparoscopic surgery patients, and to provide a more reasonable, safe and comfortable anesthesia program for female patients who undergoing laparoscopic surgery. The main questions it aims to answer are: * whether the combination of the two results on more stable hemodynamics during induction in gynecological laparoscopic surgery patients; * whether the incidence of perioperative oxidative stress and inflammation and postoperative nausea and vomiting(ponv) improved after the use of the two combinations of anesthesia induction. Participants will: * Induction of anesthesia with the experimental drug or placebo; * 5 ml of venous blood was retained before, after, and 1 day after surgery for follow-up determination of serum associated factor levels; * To record their vital signs at any point during the anaesthetic process; Serum serological indexes related to oxidative stress and inflammation were determined. The agitation during the recovery period was recorded. The incidence and severity of ponv were recorded at 2h, 2-6h, and 6-24h postoperatively, and the use of palonosetron was also recorded.
Age
40 - 60 years
Sex
ALL
Healthy Volunteers
No
Start Date
June 1, 2024
Primary Completion Date
June 1, 2026
Completion Date
June 1, 2026
Last Updated
May 22, 2024
96
ESTIMATED participants
Amobarbital
DRUG
Propofol
DRUG
Lead Sponsor
Tongji Hospital
NCT06740903
NCT06237751
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.
View ClinicalTrials.gov Terms and Conditions