Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
University of Wisconsin, Madison
Age
50–80
Sex
ALL
Healthy volunteers
Accepted
You may be eligible if
Adults who are ≥ 50 and ≤ 80 years of age
Fluent in English
Able to provide written consent
Able to complete a 2.5-3-hour clinical visit, including sitting for spectral domain optical coherence tomography (SD-OCT) imaging for 30 minutes and taking cognitive and olfactory tests for 90-120 minutes
Cognitive Ability and Family History of Alzheimer's Disease/Mild Cognitive Impairment (AD/MCI):
* Cohort 1: Cognitively unimpaired, no family history of MCI or AD, and MMSE ≥ 26
* Cohort 2: Cognitively unimpaired, a positive family history of MCI or AD, and MMSE ≥ 26
* Cohort 3: An MMSE score \> 22 and ≤ 25 and either
* Clinically diagnosed MCI due to AD
* A participant in a Wisconsin ADRC research registry with either clinically diagnosed MCI or self-reported MCI
Cohorts 1 and 2: proficient in independent use of mobile smart devices
You may not be if
A history of significant ocular or nasal trauma that required medical/surgical intervention
A history of intraocular surgery except cataract extraction
A cataract extraction within 3 months prior to enrollment
Diagnosis of visually significant intraocular disease (such as late-stage age-related macular degeneration, glaucoma, or other optic nerve conditions related to brain tumor or multiple sclerosis), drug related vision loss or retinal damage
Optic neuritis on both eyes
Current use of medications that may interfere with olfactory functions
Current use of hydroxychloroquine and tamoxifen, which are known to cause retinal toxicity that may confound OCT interpretation
A history of recurrent or chronic oto-pharyngeal-laryngeal (ORL) disease (such as chronic rhinitis, nasal polyposis, or sinus disease), head trauma, toxic exposures, upper respiratory infections at time of assessment
A family history or diagnosis of other neurodegenerative diseases (e.g., multiple sclerosis, Parkinson's disease, Huntington's disease) or conditions that, in the opinion of the Investigators, may affect cognitive or olfactory functions
Olfactory loss due to COVID (current olfactory loss and/or temporary loss that has been regained)
