ScentAware and OCT in MCI vs HC

Exclusion Criteria

• •A history of significant ocular or nasal trauma that required medical/surgical intervention
• •A history of intraocular surgery except cataract extraction
• •A cataract extraction within 3 months prior to enrollment
• •Diagnosis of visually significant intraocular disease (such as late-stage age-related macular degeneration, glaucoma, or other optic nerve conditions related to brain tumor or multiple sclerosis), drug related vision loss or retinal damage
• •Optic neuritis on both eyes
• •Current use of medications that may interfere with olfactory functions
• •Current use of hydroxychloroquine and tamoxifen, which are known to cause retinal toxicity that may confound OCT interpretation
• •A history of recurrent or chronic oto-pharyngeal-laryngeal (ORL) disease (such as chronic rhinitis, nasal polyposis, or sinus disease), head trauma, toxic exposures, upper respiratory infections at time of assessment
• •A family history or diagnosis of other neurodegenerative diseases (e.g., multiple sclerosis, Parkinson's disease, Huntington's disease) or conditions that, in the opinion of the Investigators, may affect cognitive or olfactory functions
• •Olfactory loss due to COVID (current olfactory loss and/or temporary loss that has been regained)