Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
The University of Texas Health Science Center, Houston
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
fluent in English;
Diagnosed with schizophrenia spectrum disorder that is currently stable;
Report regular cigarette smoking, average cigarette per day ≥ 5 in the past 4 weeks, and present a breath CO≥10 ppm.
Meet subjective and objective (urinary drug screen) measures of non-opioid use.
If female, present a negative pregnancy test, not be currently breast feeding, and agree to use acceptable birth control methods and receive periodic pregnancy tests during the course of the study.
Able to give written informed consent
Obtain an Evaluation to Sign Consent (ESC) score above 10.
You may not be if
Have suicidal or homicidal ideation requiring immediate attention.
Previous use of bupropion or naltrexone in the past 30 days.
Currently enrolled in treatment for tobacco use.
Meet Diagnostic and Statistical Manual of Mental Disorders (DSM-5 )criteria for alcohol and other substance use disorders excluding nicotine and marijuana.
Report a history of epilepsy, seizure disorder or condition increasing risk of seizure, or head trauma with neurological sequelae.
Have a current eating disorder.
Be medically unstable or taking medications that are contraindicated with using naltrexone or bupropion.
