Saves the questions and what to expect into your notes, next to the visit they belong to.
Keep this study
Lead
Astellas Pharma Inc
Age
18–any
Sex
ALL
Healthy volunteers
Not accepted
You may be eligible if
Participant has locally advanced (unresectable) or metastatic solid tumor malignancy with documented KRAS G12D mutation and has received prior standard therapy.
Participant has at least 1 measurable lesion per RECIST v1.1.
Participant has an ECOG performance status of 0 or 1.
Participant has adequate organ function.
You may not be if
Participant has symptomatic or untreated central nervous system (CNS) metastases. Participants with asymptomatic and treated and stable CNS metastases are eligible.
Participant has leptomeningeal disease as a manifestation of the current malignancy.
Participant has another prior malignancy active (i.e., requiring treatment or intervention) within the previous 2 years different from the primary malignancy for this study, except for local malignancies that have been apparently cured, such as basal or squamous cell skin cancer, superficial bladder cancer or carcinoma in situ of the cervix or breast, which are allowed.
Participant with active hepatitis B or hepatitis C virus (HCV).
Participant has a known history of human immunodeficiency virus (HIV) infection with acquired immunodeficiency syndrome (AIDS)-related complications.
Participant has an active infection requiring intravenous antibiotics within 14 days prior to study intervention.
Participant is expected to require another form of anticancer therapy while on study intervention.
Participant has any condition that makes the participant unsuitable for study participation.
Clareo Health | A Study to Find a Suitable Dose of ASP4396 in Adults With Solid Tumors
