Preoperative Accelerated Partial Breast Irradiation in Patients With Locally Recurrent or Second Primary Breast Cancer

Inclusion Criteria

• •Female patients ≥ 51 years
• •Ipsilateral breast cancer; recurrence or second primary
• •Either histologically proven invasive adenocarcinoma (invasive adenocarcinoma with DCIS component is also accepted) or DCIS alone (calcification associated on imaging)
• •Histologically proven estrogen receptor positive
• •HER2neu negative
• •In case of invasive adenocarcinoma: tumor size ≤ 3 cm. In case of DCIS alone: affected area ≤ 2.5 cm
• •Grade I or grade II (biopsy)
• •cN0M0 (No evidence of nodal or distant metastases on axillary ultrasound and, if indicated, positron emission tomography-computed tomography (PET-CT) scan)
• •Unifocal lesions on mammogram and MRI (small satellite lesions adjacent to the tumor are accepted as long as it is suitable for local excision)
• •Interval since completion of local treatment of primary tumor \> 12 months
• •Previous radiotherapy (whole breast or partial) of the ipsilateral breast
• •Repeat breast conserving surgery feasible
• •World Health Organization (WHO) performance ≤ 2
• •Written informed consent
• •The patient is legally competent