Schizophrenic Disorder (Diagnostic and statistical manual of mental disorders, DSM-5-TR, American Psychiatric Association, 2013)
AVHs that have resisted to at least two properly conducted antipsychotic therapies at an effective dose for at least 8 weeks (criteria of Kinon et al., 1993)
Frequent AVHs (at least 10 times per hour) (Fovet et al., 2022)
Unmodified antipsychotic dosage for 30 days prior to inclusion in the protocol
AVH are the main residual symptom of schizophrenia.
Consent to participate in the study
You may not be if
Pregnancy (based on date of last menstrual period with possibility of urine test if in doubt)
Current addictive behavior (except tobacco and cannabis, widely used in this clinical population; Fovet et al., 2022)
Contraindication to MRI (i.e., presence of ferromagnetic material or implanted neurostimulation devices due to the risk of displacement or dysfunction such as cochlear implants, cardiac pacemakers, metal splinters in the body following an accident, permanent makeup applied less than 6 months ago, neurosurgical clips, deep brain or vagus nerve stimulation devices, baclofen pumps) (Lefaucheur et al., 2011)
Morphological criteria: weight \> 130 Kg, abdominal circumference conditioned by the opening of the magnet, shoulder width
Lack of coverage by the social security system
Current participation in another interventional research protocol or being in the exclusion period of a previous research protocol
Refusal to be informed of an brain anomaly detected in the MRI
Person under guardianship or curatorship
Behavioral disorders or delusions likely to prevent the MRI or rTMS from being performed under good conditions (left to the discretion of the investigator at baseline).
Clareo Health | Reduction of Auditory-Verbal Hallucinations in Schizophrenia Through Cortical Neuromodulation
