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RECRUITINGNANCT06358807

Microfracture With Platelet Rich Plasma Gel Injection for Osteochondral Lesion of the Talus

The goal of this clinical trial is to learn if combined local injection of platelet rich plasma (PRP) gel adds clinical efficacy to isolated arthroscopic microfracture in treatment of osteochondral le...

Lead sponsor: Peking University Third Hospital•1 locations•View source on ClinicalTrials.gov

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Contacts

Qinwei Guo, MD

CONTACT

+86 18601129252 guoqinwei@vip.sina.com

Fengyi Hu, MD

CONTACT

+86 13335511505 hfy1322@pku.edu.cn

Sponsors

Lead Sponsor

Peking University Third Hospital

Age

18 - 60 years

Sex

ALL

Healthy Volunteers

No

Inclusion Criteria

•Chronic ankle pain, diagnosed as osteochondral lesion of the talus;
•Lesion size ≤ 1.5 cm2 or the diameter of the lesion ≤ 1.5 cm;
•Conservative treatment of at least 3 months fails to relieve symptoms;
•Willingness to voluntarily participate in the trial and to sign informed consent.

Exclusion Criteria

•Varus or valgus deformity of the ankle of more than 5 degrees;
•Grade III injury of the lateral collateral ligament of ankle;
•Chronic synovitis (rheumatoid arthritis, pigmented villous nodular synovitis, etc.);
•Joint fibrosis, stiffness, and significantly restricted range of motion;
•Evidence of moderate to severe knee osteoarthritis on plain radiographs;
•Failure to complete the rehabilitation protocol as required;
•Patient medically not fit for surgery, radiographs or MRI;
•For women, pregnant, planning to be pregnant or lactating.

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Data from ClinicalTrials.govLast updated on ClinicalTrials.gov: May 20, 2024Terms

Trial snapshot

StatusRECRUITING

PhaseNA

Enrollment70

Start dateJan 2024

Last updatedMay 20, 2024

Condition

Osteochondral Lesion of Talus Microfractures Platelet Rich Plasma

Locations shown

Peking University Third Hospital

Beijing

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: May 20, 2024Data synced to Clareo: April 28, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

View ClinicalTrials.gov Terms and Conditions