Closed-loop syncHronization vErsuS convenTional Synchronization in sPontaneously Breathing Adult Nonivasive ventilationPatients

Exclusion Criteria

• •Formalized ethical decision to withhold or withdraw life support
• •Patient included in another interventional research study under consent
• •Patient already enrolled in the present study in a previous episode of respiratory failure
• •Pregnant woman
• •Patients deemed at high risk for the need of transportation from an intensive care unit or emergency department to another ward, diagnostic unit or any other hospital
• •Hemodynamic instability defined as a need of continuous infusion of epinephrine or norepinephrine \> 1 mg/h
• •Not being able to obtain reference waveforms due to technical or medical problems
• •Vulnerable population
• •Increase or decrease of ventilatory support either in pressures, fraction of inspired oxygen or mode of ventilation during study period