Association of Anti-factor Xa Activity With Venous Thromboembolism in Critically Ill Patients

Exclusion Criteria

• •Therapeutic anticoagulation, defined as enoxaparin dose of at least 100 IE/kg when given twice daily or of at least 150 IE/kg when given once daily
• •Extracorporeal membrane oxygenation in place or planned within 48 hours of study enrolment
• •Planned regular administration of vitamin K antagonists, unfractionated heparin, low molecular weight heparin other than enoxaparin, thrombin inhibitors or factor X inhibitors within the observation period
• •Estimated life expectancy below 48 hours or comfort terminal care order in place
• •Previously diagnosed heparin-induced thrombocytopenia
• •Pre-operative admission for elective surgery
• •Previous enrolment in the study