GlutN : Randomized, Double-blind, Crossover Clinical Trial to Confirm the Role of Gluten in Non-celiac Gluten Sensitivity

Exclusion Criteria

• •\- Weight \< 45 kg
• •Celiac disease: presence of anti-tissue transglutaminase and/or anti-endomysium autoantibodies and/or villous atrophy found on duodenal biopsies.
• •Wheat allergy: presence of IgE specific to wheat and/or positivity of prick tests and/or patch tests.
• •Presence of another food intolerance/sensitivity, in particular to vegetables and fruits rich in FODMAPs, excluding lactose intolerance (extremely common, 30 to 50% of the French population).
• •Presence only of digestive symptoms, without extradigestive symptoms, when consuming foods containing gluten.
• •Impossibility of eliminating celiac disease: HLA DQ2 or DQ8 patient, for whom we do not have a dosage of anti-transglutaminase/anti-endomysium antibodies and/or duodenal histology on a normal diet containing gluten.
• •Current special diet: vegetarian diet except ovo-lactovegetarian or ovo-lacto-pescovegetarian (i.e. pesco-vegetarian diet, vegan/vegan diet, macrobiotic diet, etc.), Paleolithic diet, etc.
• •Pregnant or breastfeeding women.
• •Treatment in progress or for less than two months with NSAIDs, corticosteroids, antibiotics, probiotics, food supplement (glutamine, omega3, antioxidants, etc.) and any other treatment likely to interfere with the study (left to the discretion of the patient). 'investigator).
• •Current treatment or for less than 18 months with immunosuppressants, chemotherapy.
• •History of digestive surgical intervention (except cholecystectomy and appendectomy).
• •Any infectious or inflammatory pathology in progress or less than a month old and any other pathology likely to interfere with the protocol (left to the discretion of the investigator).
• •Individual under guardianship, curatorship or legal protection, or deprived of freedoms.
• •Participation in another clinical study.