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Effects of Vasopressor on Cerebral Oxygenation During General Anesthesia in Abdominal Surgery
The purpose of this study is to investigate whether norepinephrine(N), phenylephrine(P) or ephedrine(E) have different effect on cerebral oxygenation in abdominal surgery with propofol or sevoflurane.
This study was a single-center, randomized, double-blinded, controlled trial. First, the effects of E, P, or N on cerebral oxygen saturation(rScO2) under general anesthesia in abdominal surgery were studied. Patients with abdominal surgery were evaluated using near-infrared spectroscopy. Continual changes in systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial blood pressure (MAP), heart rate (HR), stroke volume (SV), cardiac output (CO) and systemic vascular resistance (SVR) will be measured with LiDCO rapidV3 monitoring system. To investigate the individualized therapeutic options \& specific mechanisms of the three vasopressors on rScO2 and CO.
Age
18 - 80 years
Sex
ALL
Healthy Volunteers
No
Dalian Municipal Central Hospital
Dalian, Liaoning, China
Start Date
March 5, 2024
Primary Completion Date
December 5, 2025
Completion Date
December 5, 2025
Last Updated
November 6, 2024
180
ESTIMATED participants
Ephedrine-P
DRUG
Phenylephrine-P
DRUG
Norepinephrine-P
DRUG
Ephedrine-S
DRUG
Phenylephrine-S
DRUG
Norepinephrine-S
DRUG
Lead Sponsor
Dalian Municipal Central Hospital
Data Source & Attribution
This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.
Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.
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View ClinicalTrials.gov Terms and ConditionsNCT05661942