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Acute Physiological Responses to Twice Daily Blood Flow Restriction Training | Clinical Trials | Clareo Health

RECRUITINGNA

Acute Physiological Responses to Twice Daily Blood Flow Restriction Training

Effects of Twice Daily Blood Flow Restriction Training on Muscle Swelling, Markers of Exercise Induced Muscle Damage and Inflammation: A Randomised Control Trial

NCT06334224•Defence Medical Rehabilitation Centre, UK

View on ClinicalTrials.gov

Summary

The Academic Department of Military Rehabilitation (ADMR) is currently conducting a pan-defence, randomised control trial (RCT) investigating the utility of twice daily blood flow restriction training in UK military personnel with persistent knee pain (NCT05719922). Due to logistical confinements, this pan-defence RCT is confined to collecting outcome data pre and post-intervention. Therefore, the acute physiological mechanisms which underpin adaptation will remain unknown. Consequently, ADMR is undertaking an additional, single centre RCT which will compare the acute physiological responses to low load resistance training with and without the addition of blood flow restriction. Specifically, this study will elucidate the effect of twice daily blood flow restriction training on measures of muscle swelling, muscle damage and inflammation. This data may aid in the optimisation of blood flow restriction exercise prescription within UK Defence Rehabilitation and elsewhere.

Eligibility

Age

18 - 55 years

Sex

ALL

Healthy Volunteers

Yes

Inclusion Criteria

•Age 18 - 55 years
•Must not have performed regular lower-limb resistance training for the last 6 months (participants must have performed \< 1 lower-limb resistance training session per week over the previous 6 months)
•DMRC Staff member (civilian or service personnel)

Exclusion Criteria

•Any medical contraindication related to BFR\*.
•Any current lower-limb musculoskeletal injury
•Restricted range of movement. i.e. Chronically locked knee or fixed flexion deformity.
•Any physical impairment or co-morbidities (including cardio-vascular disease) precluding the safe participation in the intervention and/or assessment procedures
•Non-musculoskeletal or serious pathological condition (i.e. Inflammatory arthropathy, infection or tumour).
•Use of any medication which may contraindicate the performance of BFR or influence blood biomarkers of EIMD or inflammation.
•Use of any performance enhancing supplements or ergogenic aids such as creatine monohydrate.
•Any individual who is known to be currently pregnant
•History of cardiovascular disease (hypertension, peripheral vascular disease, thrombosis/embolism, ischaemic heart disease, myocardial infarction).
•History of the following musculoskeletal disorders: rheumatoid arthritis, avascular necrosis or osteonecrosis, severe osteoarthritis.
+9 more criteria

Locations (1)

Defence Medical Rehabilitation Centre

Loughborough, United Kingdom

Key Dates

Start Date

November 6, 2023

Primary Completion Date

September 1, 2024

Completion Date

September 1, 2024

Last Updated

March 27, 2024

Enrollment

ESTIMATED participants

Conditions

Muscle WeaknessMuscle Damage

Interventions

Low load resistance training with blood flow restriction

DEVICE

Low load resistance training

OTHER

Contacts

Peter Ladlow, PhD

CONTACT

+44 (0)1509 251 500 peter.ladlow100@mod.gov.uk

Russ Coppack, PhD

CONTACT

+44 (0)1509 251 500 Russ.Coppack100@mod.gov.uk

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Data Source & Attribution

This clinical trial information is sourced from ClinicalTrials.gov, a service of the U.S. National Institutes of Health.

ClinicalTrials.gov last update: March 27, 2024Data synced to Clareo: March 29, 2026

Modifications: This data has been reformatted for display purposes. Eligibility criteria have been parsed into inclusion/exclusion sections. Location data has been geocoded to enable distance-based search. For the authoritative and most current information, please visit ClinicalTrials.gov.

Neither the United States Government nor Clareo Health make any warranties regarding the data. Check ClinicalTrials.gov frequently for updates.

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Acute Physiological Responses to Twice Daily Blood Flow Restriction Training

Inclusion Criteria

Exclusion Criteria

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